The transforming growth facor beta (TGF-ß) superfamily is a large family of growth factors named after the first member TGF-ß1. Members of TGF-ß superfamily are similar in structure. TGF-ß superfamily distributes in invertebrates as well as vertebrates species. They play role in dorso-ventral patterning, mesoderm induction and patterning, and also in limb bud formation, bone and cartilage formation, neuron differentiation. So TGF-ß superfamily is important in development of a variety of different tissues and organs. http://tinyurl.com/z2gw3ln
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